T cell Immunoglobulin and Mucin Domain Containing Protein 3 (TIM-3) Inhibitors in Oncology Clinical Trials: A Review

T cell Immunoglobulin and Mucin Domain Containing Protein 3 (TIM-3) Inhibitors in Oncology Clinical Trials: A Review

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ABSTRACT: T cell immunoglobulin and mucin domain containing protein 3 (TIM-3) is a receptor found on a multitude of immune cells and sheepshead bay boats is commonly overexpressed in patients with cancer.Due to its selective expression in immune cells and its preliminary efficacy in preclinical models, TIM-3 is a promising target as a treatment for cancer.Both monotherapy and combination regimens nacrack.com are being developed and are currently under investigation.This clinical review seeks to summarize and compile past, present, and future TIM-3 inhibitors in clinical trials.